Bruno Vassari Hyaluronic Acid Multi Molecular Filler 15ml

Bruno Vassari Hyaluronic Acid Multi Molecular Filler Concentrated Hyaluronic acid Helps maintain smooth and moisturized skin. Maintaining moisturized skin is essential for maintaining a healthy and vibrant cutis. With age, the skin gradually loses key structural components and protective barrier properties. This leads to dryness, irritation and the creation of fine lines and wrinkles. Using this serum prevents dryness of the skin, restores the properties of the natural protective barrier, and improves softness, elasticity and tone. Ideal for all types of skin, including people with sensitive skin. The skin feels rejuvenated and firm, elastic and flexible. What are the Actives in Bruno Vassari Hyaluronic Acid Multi Molecular Filler 1. Hyaluronic Acid Low Molecular Weight 2. Hyaluronic Acid High Molecular Weight How to use Bruno Vassari Hyaluronic Acid Multi Molecular Filler? Apply day and night after the skin cleansing and before your cream. Which types of skin can use Bruno Vassari Hyaluronic Acid Multi Molecular Filler? – Ideal for all types of skin, including people with sensitive skin Hyaluronic Acid in Bruno Vassari Hyaluronic Acid Multi Molecular Filler High molecular weight hyaluronic acid in Bruno Vassari Hyaluronic Acid Multi Molecular Filler Most probably it does not penetrate the skin. There is a lonely study from 1999 that thinks that HA can absorb into the skin through some active transport mechanism, however, we could not find anything to confirm this. What we could find is multiple expert opinions and newer studies that state HMW-HA is a huge molecule that stays on top of the skin to give surface hydration and to form a protective barrier.   Not only that, but it can also work as an “osmotic pump”, meaning it can be a penetration enhancer for water-soluble actives. HA can be an “osmotic delivery system that can push water-soluble actives deeper into the skin by forming a highly hydrated reservoir on the surface of the skin”.   Think of HMW-HA it as a sponge. HMW-HA has superstar water-binding abilities. It can bind 1000 times its own weight in water. Or to say it another way 1 gram of HA can bind up to 6 liters of water! That is a lot, and this makes HA pretty much the best water-binding ingredient we know today   It is really the sponge of our skin: it’s there in the outer layers and helps our skin immensely to attract and retain its water content. Not only that, but HA has lots of other important biological functions.   Apart from hydration, the skin-related functions include maintaining the skin’s elasticity, reducing the skin’s inflammatory response, regenerating the damaged skin barrier and plumping up water-loss related wrinkles. Essentially, helping the skin to look and feel healthy and young Low molecular weight hyaluronic acid in Bruno Vassari Hyaluronic Acid Multi Molecular Filler The biological function of LMW-HA in the skin seems to be crazy complicated and different than that of HMW-HA. LMW-HA is mostly created when HMW-HA is chopped up into smaller pieces at sites of an injury and it is thought to be a pro-inflammatory signal molecule.   Based on LMW-HA’s biological role, the question is logical: is LMW-HA pro-inflammatory when we smear it on? Well, it is a good question and we do not have the surefire answer. Most evidence points so far to a no, at least when it comes to molecular weights in the 50kDa and up range.   First, LMW-HA is still a big-big molecule whose penetration is questionable. It might absorb a bit better than HMW-HA, but that still means working mostly in the epidermis, the uppermost layers of the skin. Second, we found multiple studies showing that LMW-HA can help the skin to repair itself.   One study showed that 0.2% LMW-HA (~ 200kDa used in the study) increases the skin’s self-defense and another two studies found LMW-HA (also in 0.2%) to be helpful for inflammation-related skin diseases such as rosacea and facial seborrheic dermatitis.   Third, a manufacturer-related study (done by Evonik) found that HA versions with a molecular-weight of 50kDa and up do not induce inflammatory signals in the skin, however, the 20kDa version did show some pro-inflammatory activity. Granted, this was done on reconstituted human epidermis, so it might or might not be like this on real human skin.   They also found in-vivo (on real people) that the LMW-HA versions, especially the one with 50kDa MW can plump up wrinkles really good.   So based on LMW-HA’s biological role and the Evonik study, you might want to be careful with ultra-low molecular weights, the ones below 50kDa. However, this is also not a sure thing   We also saw manufacturer data showing that a 10kDa molecular weight HA version has better antioxidant activity than a 1.6MDa version and it also had better sun protection and after-sun repair abilities than the higher MW versions.